The Diabetes Clinical Research Program (DCRP) maintains a biorepository of human blood samples for the study of type 1 diabetes (T1D), with samples and patient histories under collection for 2 decades, alongside substantive immunological assay data. We also play a central role in national and international consortia and clinical trial networks, with a focus on identifying biomarkers predictive of clinical outcomes in diabetes and identification of predictors of response to therapy. Specifically, BRI houses the chair of the NIH-funded Type 1 Diabetes TrialNet consortium, and sees study participants for TrialNet trials. By working closely with translational scientists at BRI, DCRP supports broad efforts to understand the human immune system, how it changes in the context of autoimmunity, and what drives immune differences between healthy people.
The Staff Scientist conducts research relevant to multiple current projects within the department, including the Sound Life Project, several type 1 diabetes studies including TrialNet-associated mechanistic studies, and ongoing COVID-19 research. The successful applicant will interface with scientific collaborators to optimize research study designs and patient selection, mediate access to internal sample repositories and clinical data, and facilitate data sharing and analysis. Ability to communicate scientific concepts to fellow investigators and lay people is a critical element of the position, both in talks and in writing. This role may involve some “bench time” but will primarily focus on writing and data analysis.
• Maintain and analyze Sound Life Project mass cytometry datasets
• Collaborate closely with BRI’s bioinformatics team to develop and streamline analytical approaches for Sound Life Project datasets, including mass cytometry, single cell RNAseq, and single cell ATACseq data
• Collaborate with leaders in immunological research, including BRI PIs and external investigators worldwide
• Prepare literature reviews and data to aide in writing grants and publications; present data as needed
• Learn and share knowledge about type 1 diabetes clinical research, specifically regarding trial outcomes and diabetes biomarkers
• Query, clean, and share clinical datasets related to diabetes, COVID19, and other ongoing translational research studies
• Track timelines for grants and pharma studies; prepare progress reports
• Perform other responsibilities as required
• Ph.D, preferably in immunology but related fields acceptable
• Minimum of three years of related postdoctoral training
• Prefer experience with flow and/or mass cytometry and exposure to large datasets
• Exposure to clinical research a plus, such as development of IRB protocols
• Attention to detail and science writing experience are required
• Training in statistical analysis would be beneficial but not required
• The Staff Scientist is a highly collaborative team player who welcomes challenges
All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, citizenship, disability or protected veteran status.