Staff Scientist

Employment Type
Regular Full-Time
Requisition number
1683
Department
Kwok Lab
Location : City
Seattle

Overview

The Kwok Lab uses class II MHC multimer reagents and other state of art technologies, including single cell RNAseq experiments in examining antigen specific CD4+ T Cells in infectious diseases, peanut allergy, type 1 diabetes and rheumatoid arthritis.

Responsibilities

  • Lead experiments in producing soluble MHC multimer reagents, including construct design and protein purification
  • Lead experiments in using MHC multimer reagents in examining epitope specific T cells
  • Carry out bench work experiments, including cell culture, flow cytometry assays and be responsible for checking and validating the results in each field of activity.
  • Implement adequate experimental protocols and, if necessary, the experiments required to solve the possible technical problems within study deadlines.
  • Provide guidance to research technicians in producing and utilizing MHC multimer reagents
  • Present results or summary of results to the project team or to other audiences as needed
  • Write required documents such as experimental procedures, research articles and study reports.
  • Provide oversight/ supervision of technicians or graduate students within the context of these studies.

Requirements

  • PhD Degree in Immunology/Biochemistry or similar discipline with a minimum 3 years of postdoctoral experience.
  • Experience in expression construct design, protein purification from mammalian cells and working with T cells.
  • Specific specialization on human T and/or B cell immunology is required. Previous experience with MHC multimer staining, RNAseq, or knowledge in bioinformatics is a plus.
  • Significant experience in multi-parameter flow cytometry, and in design/set up of cell based assays. Additional expertise in other laboratory techniques related to molecular biology and biochemistry research will also be considered.
  • Excellent verbal and written communication skills with good organizational and analytical abilities.


All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, citizenship, disability or protected veteran status.

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