The Center for Systems Immunology at the Benaroya Research Institute (BRI) seeks to recruit an outstanding candidate for a Bioinformatics position in Dynamic Systems Biology.
The goal of our group is to study and characterize the dynamical behavior of the immune system in health and disease and develop an operational understanding of how nonlinearities in interactions among the system components govern response to external perturbations such as vaccines and drugs. While our primary focus is the immune system, we explore longitudinal behavior with multiscale datasets including, but not limited to, cytometry, single- and bulk- RNA-seq, proteomics and perturbation-omics data.
The phenomena that we study include all kinds of time-varying behavior such as breadth of immunotype heterogeneity across populations, resilience of immunotype variability over time, and acute responses to vaccines and drugs. The candidate will work closely with other bioinformaticians and immunologists at BRI, resulting in a rich environment for quantitative, computational, and laboratory collaborations in immune disease research.
This position is open to candidates located anywhere within the U.S.A. The candidate will have the option to work remotely from home.
• Perform biostatistical or other bioinformatics based analysis working with institute scientists, including generating quality control and data output reports, visualizations, and publication-quality graphics where appropriate.
• Critically evaluate experimental design and its relationship to bioinformatics analysis.
• Work independently and collaboratively with all levels of institute researchers, in a dynamic research environment to design and implement new immunological experiments.
• Participate in writing quarterly reports, progress reports, proposals, and journal articles.
• Keep informed of cutting-edge ideas, research, and technology, and apply them as appropriate.
• Update the Systems Immunology Division on new data analysis methods and publications.
• Educate institute scientists in bioinformatics and biostatistics through open door consulting and classroom sessions.
• Attend and present data at external scientific meetings and conferences as appropriate.
• Meet established deadlines and milestones.
• Comply with health & safety procedures and practices.
• Perform other duties as required.
• Demonstrates success in technical proficiency, scientific creativity, collaboration with others as well as independent thought
• Excellent oral and written communication skills
• Excellent time management, task organization, and multi-tasking skills.
• Proficiency in laboratory information and general data management skills.
• Has a solid understanding and knowledge of the scientific basis of their field.
• Understands the principles of molecular biology, genetics, and immunology.
• Proficiency operating in a mixed UNIX-Mac-Windows environment.
• Programming skills in Unix shell scripting languages (sh/sed/awk), other scripting languages (Perl, Python), and at least one high-level programming language such as C or Java.
• Proficiency with bioinformatics analysis software such as R/Bioconductor, SAS/JMP Genomics.
• A focus or strength in one or more areas of bioinformatics such as experimental design, RNA-seq analysis, genomic assembly, biostatistics, machine learning, data visualization, etc.
• Bioinformatician I: B.S. or M.S. in bioinformatics, biostatistics, or other life science with a strong understanding of the principals of bioinformatics, and 0-3 years related experience.
• Bioinformatician II: Ph.D: in bioinformatics, biostatistics, or other life science with a strong understanding of the principals of bioinformatics, and 3 or more years related experience; alternatively an M.S. in the above listed fields and 6 or more years experience.
All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, citizenship, disability or protected veteran status.