The Buckner Lab at the Benaroya Research Institute in Seattle, Washington is renowned for expertise in translational immunology and human autoimmune disease. Research in the Buckner Lab focuses on identifying the underlying mechanisms by which the adaptive immune response to self-antigen becomes pathogenic in the setting of human autoimmune study. They use cutting edge techniques and primary human immune cells to study the following autoimmune diseases: type 1 diabetes (T1D), rheumatoid arthritis (RA), muliple sclerosis (MS), systemic lupus erythematosus and irAE in Cancer immunotherapy.  They have extensive experience in MHC class II tetramers, T cell cloning, T and B cell functional assays, gene editing and phenotyping of human lymphocytes.   Potential projects in the Buckner Lab include: - Development of regulatory T cell - based therapies - Identification and characterization of antigen-specific T cells in rheumatoid arthritis - Genotype-phenotype studies of genetic variants associated with autoimmune disease - T cell response to cytokines in autoimmune disease. - irAE in the setting of cancer immunotherapies

The Benaroya Research Institute is offering an opportunity for an early career clinical scientist to join our Center for Interventional Immunology.  As a leader in immunology discovery and clinical research, the Benaroya Research Institute in Seattle, WA provides a unique environment for a physician investigator to focus on understanding the immune and metabolic causes and consequences of human autoimmunity and Type 1 diabetes.  We offer a superb training environment for early investigators. The BRI faculty include outstanding NIH funded laboratory and clinically based investigators providing a robust scientific milieu and focused mentorship to facilitate the development of clinician scientists.  Our group has leadership roles in NIH sponsored programs such as Diabetes TrialNet and the Immune Tolerance Network providing networking opportunities for early career investigators.  Based in Seattle, we are in a robust research environment with established collaborations in teaching and/or research with the University of Washington, Fred Hutch Cancer Center, Seattle Children’s Hospital and Research Institute, and industry partners. For pediatricians, the position may include joint clinical appointments with Seattle Children’s Hospital.

The Genomics Core Laboratoryat BRI provides cutting edge technologies, including Illumina Next Generation Sequencing and 10x Genomics single cell analyses, to study gene expression, proteomics, and epigenetics in single cells and bulk populations. The laboratory works collaboratively with investigators at BRI and at a number of external sites to further a wide variety of studies of autoimmune disease, allergy and asthma, and infectious disease and offers the chance to make a real impact in understanding the immune system and its role in health and disease. 

Combatting Immune Disease Through Data Analysis! Join our team to help fight immune diseases.    We need individuals to apply cutting edge statistical approaches to study the human immune system. We believe that understanding how the immune system functions both in health and in diseases like cancer and autoimmunity will lead to better patient care. We are looking for highly motivated and creative individuals who enjoy working in a multidisciplinary team-oriented environment to use statistical and computational approaches to discover new mechanisms, biomarkers, and therapies for immune-mediated diseases. The biostatistician will integrate with two teams: 1) our Center for Systems Immunology, a dynamic group of bioinformaticians, immunologists, and other data analysts, and 2) the Center for Interventional Immunology to help design and analyze data from clinical research studies.   Benaroya Research Institute at Virginia Mason (BRI) is an internationally recognized medical research institute committed to finding a cure for autoimmune and immune-mediated diseases, through a combination of basic and translational research programs. This means you can contribute to scientific advances that have a direct impact on people with these diseases, including type 1 diabetes, rheumatoid arthritis, multiple sclerosis, allergies, and asthma.

Combatting Immune Disease Through Data Analysis! Join our team to help fight immune diseases.    We need individuals to apply cutting edge statistical approaches to study the human immune system. We believe that understanding how the immune system functions both in health and in diseases like cancer and autoimmunity will lead to better patient care. We are looking for highly motivated and creative individuals who enjoy working in a multidisciplinary team-oriented environment to use statistical and computational approaches to discover new mechanisms, biomarkers, and therapies for immune-mediated diseases. The biostatistician will integrate with two teams: 1) our Center for Systems Immunology, a dynamic group of bioinformaticians, immunologists, and other data analysts, and 2) the Center for Interventional Immunology to help design and analyze data from clinical research studies.   Benaroya Research Institute at Virginia Mason (BRI) is an internationally recognized medical research institute committed to finding a cure for autoimmune and immune-mediated diseases, through a combination of basic and translational research programs. This means you can contribute to scientific advances that have a direct impact on people with these diseases, including type 1 diabetes, rheumatoid arthritis, multiple sclerosis, allergies, and asthma.

The Center for Systems Immunology at Benaroya Research Institute (BRI) in Seattle, WA seeks to recruit outstanding applicants for a new faculty position at the assistant or associate level. We seek candidates who use experimental and/or computational systems approaches that can be applied to study immune system functions in health and disease, with a particular emphasis on autoimmune diseases, mucosal immunology, allergy and cancer. This position offers a unique opportunity to bridge cutting-edge systems approaches with world class research in basic and translational immunology in a highly interactive and collaborative environment. Current research in the center includes programs aimed at identifying molecular signatures of pathogenic immune cells and determining how genetic variation tunes immune cell responses using the latest single cell and genetic screening approaches. The Center for Systems Immunology offers state of the art laboratory and sequencing resources, with a dedicated computational cluster, genomics core, and bioinformatics group with expertise in integrating and analyzing the latest sequencing and cytometry-based technologies. As part of the Seattle research community, BRI benefits from a rich and collaborative academic environment, with multiple major universities, research institutions, hospitals, and industry partners in close proximity. About BRI.  BRI is one of the few research institutes in the world devoted to finding causes and cures for immune system diseases and is an international leader in translating discoveries in autoimmune diseases to real life applications. Research at BRI encompasses many approaches, from studies of fundamental immunology processes, genetics and translational studies, to clinical trials. BRI is powered by excellent laboratory facilities, an extensive biorepository of samples from autoimmune patients and healthy subjects, and houses two international clinical research networks, the Immune Tolerance Network and Type 1 Diabetes TrialNet. Read more about BRI at www.benaroyaresearch.org.

The Benaroya Research Institute (BRI) seeks to recruit outstanding applicants for a new Assistant Member faculty position to join our Center for Interventional Immunology. As a leader in immunology discovery and clinical research, the Benaroya Research Institute in Seattle, WA provides a unique environment for an investigator to focus on understanding the causes and consequences of human autoimmunity including Type 1 diabetes.  BRI offers a superb training environment for early investigators. The BRI faculty include outstanding NIH funded laboratory and clinically based investigators providing a robust scientific milieu and focused mentorship to facilitate the development of researchers with a clinical research focus.  Our group has leadership roles in NIH sponsored programs such as Diabetes TrialNet and the Immune Tolerance Network providing networking opportunities for early career investigators.  Based in Seattle, we are in a robust research environment with established collaborations in teaching and/or research with the University of Washington, Fred Hutch Cancer Center, Seattle Children’s Hospital and Research Institute, and industry partners. The BRI Center for Interventional Immunology includes scientific and clinical investigators, clinicians, and a cadre of experienced clinical coordinators and support staff. Together, we conduct clinical trials designed to alter immune mediated disease such as type 1 diabetes, rheumatologic diseases and others.  We also conduct  clinical research investigations involving basic physiology studies and development and testing of biomarkers. In addition, the program maintains a robust immune mediated diseases registry and repository for translational studies. The repository contains thousands of patient samples well characterized by genetic, immune and clinical parameters.

The Animal Technician II-III provides for the basic health and husbandry needs of rodents (mice only) housed in the vivarium, processes equipment, and performs some colony management tasks. The job title and expected major responsibilities will be determined based on prior experience.   This is an essential position which means that punctuality as well as the ability to report to work, even during inclement weather, and on some holidays or other times when BRI suspends operations, is required. We are seeking a candidate to work 20 hours a week. The schedule for this position will be: Saturday and Sunday; 7:00am – 3:30pm. The remaining 4 hours to complete 20 hrs./week is negotiable.

The Research Assistant (RA) would offer support in a variety of studies that we conduct as well as the various phases of study development. The RA will be working on cancer related studies, with patient visits occurring in the downtown Seattle Virginia Mason Franciscan Health outpatient oncology clinic. We have unparalleled support from our physicians, clinic staff and study staff.  We are searching for an RA that would support the Clinical Research Coordinators and assist with a variety of duties related to the conduct of oncology clinical research protocols.   This is not a lab-based position.

The Center for Fundamental Immunology uses advanced tools, technologies and methods to study the genes, cells and molecules in the immune system.  This work-study position is for 10 to 19 hours each week. 

The Harrison Lab studies the mechanisms controlling host-microbe interactions at barrier tissues, primarily the skin and the gut. We perform our research in a multidisciplinary and collaborative manner, combining in vivo cellular and molecular immunology, using genetic mouse models, microbiology, transcriptomic, and epigenetic analyses, to understand how commensal-specific immunity contributes to tissue homeostasis and repair.  This position is part-time (15 to 19 hours per week). 

The goal of the Harrison Lab is to understand how immune cells promote barrier tissue integrity and repair, and to understand how this goes awry during disease.  This work-study position is for 15 to 19 hours each week. 

Diseases currently being studied in the Kwok Lab include peanut allergy, cat allergy, grass pollen allergy, type 1 diabetes, rheumatoid arthritis, Shingrix and COVID-19.  The laboratory environment provides an excellent opportunity to learn human immunology and the roles of antigen specific CD4+ T cells in different diseases.  This work-study position is for 12 to 19 hours each week. 

The Human Immunophenotyping (HIP) core at the Benaroya Research Institute (BRI) provides access to cutting-edge technologies and services enabling study of human immune-mediated diseases. The hours of this work-study position are flexible up to 12 hours each week, during the hours of 8:00 am to 4:00 pm, Monday to Friday. 

The research in the Hamerman Lab will lead to a better mechanistic understanding of how myeloid cells contribute to autoimmune and inflammatory diseases. The student will benefit by learning biological laboratory techniques including DNA isolation, PCR, gel electrophoresis as well as how to keep laboratory notes. The student will also learn about cells of the immune system and autoimmune diseases.   This work-study position is for 10 to 15 hours each week. 

The Khor laboratory is a high-mentoring environment currently seeking a highly motivated and creative individual for the position of Postdoctoral Research Associate. The scientist will be engaged in studying novel pathways regulating inflammation and autoimmunity, particularly in the context of Down syndrome. Work includes both human and animal models and is highly collaborative and cross-disciplinary. Immunology, in vivo mouse model and systems biology experience is highly desirable.  Our goal is to empower precision therapy of immune-medicated diseases in people with and without down syndrome.

The Khor laboratory is seeking a highly motivated and creative individual for the position of Research Technician I. The individual will be engaged in studying novel pathways regulating inflammation and autoimmunity, particularly in the context of Down syndrome. The individual will be responsible for providing technical laboratory support for biomedical research projects performing both routine and non-routine lab procedures. This is a transitory training position; the selected individual will receive strong mentoring to promote scientific growth and development.