Combatting Immune Disease Through Genomics Analysis! Come join our team and help fight immune diseases.    We need individuals to apply cutting edge big data approaches to study the human immune system. We believe that understanding how the immune system is broken in diseases like cancer and autoimmunity will lead to better patient care. We are looking for highly motivated and creative individuals who enjoy working in a multidisciplinary team-oriented environment to use Systems Biology approaches to discover new mechanisms, biomarkers and therapies for immune diseases.    Benaroya Research Institute at Virginia Mason (BRI) is an internationally recognized medical research institute committed to finding a cure for autoimmune and immune-mediated diseases, through a combination of basic and translational research programs. This means you can contribute to scientific advances that have a direct impact on people afflicted with these diseases, including type 1 diabetes, rheumatoid arthritis, multiple sclerosis, allergies, and asthma. BRI research leadership has identified Bioinformatics as a key enabling technology, so there is broad and strong support for the analysis, and visualization of research data.  

The Harrison Lab at the Benaroya Research Institute (BRI) in Seattle, WA is seeking highly-motivated postdoctoral candidates in the areas of mucosal immunology, specifically T and B cell responses to commensal microbes. Benaroya Research Institute is an internationally recognized medical research institute focused on finding cures for autoimmune and immune-mediated diseases. We stress excellence in advanced laboratory experimentation and carefully designed translational research programs. This offers our scientists the opportunity to directly impact the lives of people suffering from diseases including type 1 diabetes, rheumatoid arthritis, multiple sclerosis, allergies and asthma. The Harrison Lab (www.harrison-lab.org) works to understand the mechanisms controlling host-microbe interactions at barrier sites such as the skin and gastrointestinal tract. We study how our resident commensal microbes influence the development, education and function of our immune system. To do so, we utilize a multi-disciplinary approach combining development and implementation of tools to track commensal-specific T and B cells in healthy and inflamed tissues, with single-cell and population level transcriptomics and epigenetic analyses of T and B cell differentiation to investigate how the host mounts and regulates immunity to the microbiome.

The Long Lab, at the Benaroya Research Institute, is a translational immunology lab focused on better understanding underlying mechanisms of the autoimmune disease, type 1 diabetes. This is done by performing mechanistic studies associated with clinical trials and in-depth studies using clinical samples.  In fact, we have been involved in the majority of studies cited in a recent Science T1D special section review (Science 373, 510-516, 2021).  This position provides the unique opportunity to focus on mechanistic studies associated with additional clinical trials in T1D targeting T cells or cytokine pathways.

This highly collaborative 2+ year position, at the Benaroya Research Institute, provides a unique opportunity for multi-disciplinary research spanning Systems Immunologyand the Human Immunophenotyping (HIP) Core/Long Lab, under the guidance of Dr. Hamid Bolouri and Dr. Alice Long. The HIP Coreand Long Labare translational immunology labs that study autoimmunity by using cytometry-based assays on samples from clinical trials paired with selected samples to better understand mechanisms of disease.  The Bolouri Lab is focused on developing and applying computational systems immunology methods to better understand immune dysregulation in autoimmunity, cancer, and infection. We are seeking a bioinformatics scholar with strong interests in high-dimensional flow and mass cytometry, omics technologies, and systems immunology, as well as deep expertise in the development and application of bioinformatics methods and tools to emerging challenges in immunology research. Together, we hope to foster creative thinking that will move the field closer to treatments of immune mediated diseases.

This highly collaborative postdoc position, at the Benaroya Research Institute, provides a unique opportunity for multi-disciplinary research spanning Systems Immunologyand the Human Immunophenotyping (HIP) Core/Long Lab, under the guidance of Dr. Hamid Bolouri and Dr. Alice Long at the Benaroya Research Institute.  The HIP Coreand Long Labare translational immunology labs that study autoimmunity by using cytometry-based assays on samples from clinical trials paired with selected samples to better understand mechanisms of disease.  The Bolouri Lab is focused on developing and applying computational systems immunology methods to better understand immune dysregulation in autoimmunity, cancer, and infection. We are seeking a bioinformatics scholar with strong interests in high-dimensional flow and mass cytometry, omics technologies, and systems immunology, as well as deep expertise in the development and application of bioinformatics methods and tools to emerging challenges in immunology research. Together, we hope to foster creative thinking that will move the field closer to treatments of immune mediated diseases.

Combatting Immune Disease Through Systems Analysis    Come join our team and help fight immune diseases   Benaroya Research Institute needs individuals to apply cutting edge big data approaches to study of the human immune system. We believe that understanding how the immune system is broken in diseases like cancer and autoimmunity will lead to better patient care. We are looking for highly motivated and creative individuals who enjoy working in a multidisciplinary team-oriented environment to use Systems Biology approaches to help discover new mechanisms, biomarkers, and therapies for immune diseases. Successful candidates will receive a unique system of co-mentoring. They will reside in the Center for Systems Immunology at BRI and receive primary mentorship and training there. They will also collaborate closely with and be co-mentored by world class investigators expert in varied immune diseases and disease models throughout the Institute and elsewhere.

This translational immunologist collaborative position, at the Benaroya Research Institute, provides a unique opportunity to explore the potentially protective role of exhausted CD8 T cells in type 1 diabetes (T1D) by integrating immunology and systems biology skill sets. The Long Lab is a translational immunology lab focused on better understanding underlying mechanisms of autoimmune disease, patient variability, and response to therapy. Currently, we are primarily focused on three, inter-related projects in the setting of T1D: 1) Causes and consequences of reduced response to IL-2, 2) Differentiation and stability of CD8 T cell exhaustion associated with better outcome, and 3) identification of biomarkers of T1D severity. Each of these projects use human samples, are collaborative in context working with the diabetes team and systems immunology, and use the resources of the BRI Human Immunophenotyping (HIP) Core, supervised by Dr. Alice Long.

This translational immunologist collaborative position provides a unique opportunity to explore the potentially protective role of exhausted CD8 T cells in type 1 diabetes (T1D) by integrating immunology and systems biology skill sets.   The Long Lab, at the Benaroya Research Institute, is a translational immunology lab focused on better understanding underlying mechanisms of autoimmune disease, patient variability, and response to therapy.  Currently, we are primarily focused on three, inter-related projects in the setting of T1D: 1) Causes and consequences of reduced response to IL-2, 2) Differentiation and stability of CD8 T cell exhaustion associated with better outcome, and 3) identification of biomarkers of T1D severity.    Each of these projects use human samples, are collaborative in context working with the diabetes team and systems immunology, and use the resources of the BRI Human Immunophenotyping (HIP) Core, supervised by Dr. Alice Long. 

The Kwok Lab, at the Benaroya Research Institute (BRI) in Seattle, Washington is seeking a Postdoctoral Research Associate to join a lab that uses class II tetramer reagents and other state of art technologies, including single cell RNAseq experiments in examining antigen specific CD4+ T cells infectious diseases, peanut allergy, type 1 diabetes and rheumatoid arthritis.

The Buckner Lab at the Benaroya Research Institute in Seattle, Washington is renowned for expertise in translational immunology and human autoimmune disease. Research in the Buckner Lab focuses on identifying the underlying mechanisms by which the adaptive immune response to self-antigen becomes pathogenic in the setting of human autoimmune study. They use cutting edge techniques and primary human immune cells to study the following autoimmune diseases: type 1 diabetes (T1D), rheumatoid arthritis (RA), muliple sclerosis (MS), systemic lupus erythematosus and irAE in Cancer immunotherapy.  They have extensive experience in MHC class II tetramers, T cell cloning, T and B cell functional assays, gene editing and phenotyping of human lymphocytes.   Potential projects in the Buckner Lab include: - Development of regulatory T cell - based therapies - Identification and characterization of antigen-specific T cells in rheumatoid arthritis - Genotype-phenotype studies of genetic variants associated with autoimmune disease - T cell response to cytokines in autoimmune disease. - irAE in the setting of cancer immunotherapies

Benaroya Research Institute at Virginia Mason (BRI) has a bold mission: Predict, prevent, reverse and cure immune system diseases, from autoimmune disease to cancer to COVID-19. We examine the immune system in both health and disease to understand how disorders start and how to rebalance the immune system back to health. Equipped with innovative tools and robust biorepositories, our team chips away at the biggest mysteries behind these conditions to work toward our vision of a healthy immune system for all. As an independent non-profit organization within Virginia Mason Franciscan Health, we collaborate with clinicians to accelerate the path from innovative lab discoveries to life-changing patient care.   At BRI, each role is valued and an important contributor to the vision and mission. BRI is committed to a safe, caring and diverse workplace; as well as to taking action to further our commitments to foster inclusion, equity and belonging so employees feel comfortable bringing their full selves to work. Consider making a difference, join our team. Because together, we are Powering Possibility.   Visit BenaroyaResearch.org or follow BRI’s Autoimmune Life Blog, Facebook, Instagram,  LinkedIn or Twitter to learn more.     The Clinical Research Accounting Specialist has primary responsibility for all aspects of invoicing and investigation of Clinical Research Program receivables.

Combatting Immune Disease Through Data Analysis!   Come join our team and help fight immune diseases.    The bioinformatics team in the Systems Immunology Center at BRI is committed to using cutting edge big data approaches to study the human immune system. We believe that understanding how the immune system is broken in diseases like cancer and autoimmunity will lead to better patient care. We are looking for highly motivated and creative individuals who enjoy working in a multidisciplinary team-oriented environment to help collect, store, organize and manage data and data analysis products generated during scientific studies. We are looking for candidates with knowledge of biology and/or data management to provide data stewardship for our team.   Benaroya Research Institute at Virginia Mason (BRI) has a bold mission: Predict, prevent, reverse and cure immune system diseases, from autoimmune disease to cancer to COVID-19. We examine the immune system in both health and disease to understand how disorders start and how to rebalance the immune system back to health. Equipped with innovative tools and robust biorepositories, our team chips away at the biggest mysteries behind these conditions to work toward our vision of a healthy immune system for all. As an independent non-profit organization within Virginia Mason Franciscan Health, we collaborate with clinicians to accelerate the path from innovative lab discoveries to life-changing patient care.  At BRI, each role is valued and an important contributor to the vision and mission. BRI is committed to a safe, caring and diverse workplace; as well as to taking action to further our commitments to foster inclusion, equity and belonging so employees feel comfortable bringing their full selves to work. Consider making a difference, join our team. Because together, we are Powering Possibility.

The Clinical Core Laboratory (CCL) at BRI provides sample processing, archiving and distribution services for clinical research projects conducted at BRI. While this is not a research position, the CCL’s sample management services are an integral part of the clinical research which takes place at Benaroya Research Institute. 

This entry level research technician position provides a unique opportunity to learn new concepts and techniques while working with PhD level scientists to determine the potentially protective role of exhausted CD8 T cells in type 1 diabetes (T1D), building from past publications (Long, et.al., Sci Imm, Wiedeman, et.al., JCI). The Long Lab is a translational immunology lab focused on better understanding underlying mechanisms of autoimmune disease, patient variability, and response to therapy. Currently, we are primarily focused on three, inter-related projects in the setting of T1D: 1) Causes and consequences of reduced response to IL-2, 2) Differentiation and stability of CD8 T cell exhaustion associated with better outcome, and 3) identification of biomarkers of T1D severity. Each of these projects use human samples, are collaborative in context working with the diabetes team and systems immunology, and use the resources of the BRI Human Immunophenotyping (HIP) Core. By providing these opportunities, I hope to foster creative thinking and collaboration in my lab that will move the field closer to treatments of autoimmunity. This learning environment has enabled multiple technicians from my lab to successfully move to higher education (graduate school, medical school) and more advanced positions in industry. 

The Animal Cage Washer is needed to provide the basic husbandry needs of the rodents housed in the vivarium by cleaning and sterilizing caging and other equipment while maintaining supplies and the general appearance and cleanliness of the facility. 

Benaroya Research Institute at Virginia Mason (BRI) in Seattle, WA is an internationally recognized non-profit medical research institute affiliated with the Virginia Mason Health System. The Clinical Trials Unit at Benaroya Research Institute works primarily with the physicians at Virginia Mason on Industry/Grant Funded studies that focus on their area of expertise. The main departments we work closely with are Neurology, Asthma/Allergy, Cardiology, and Rheumatology. Currently we are also working with the Infectious Disease department on COVID-19 protocols.

The Clinical Research Program at the Benaroya Research Institute at Virginia Mason (BRI) is committed to giving patients access to clinical trials.  Working with clinicians at Virginia Mason Franciscan Health (VMFH), the Clinical Research Program at BRI differentiates itself by focusing on patient-centered research.  BRI is an independent, non-profit organization with a culture based on the values of collaboration, respect, innovation and inquiry.  Team members work together to support patients and clinicians with the goal of better outcomes for all.   Visit BenaroyaResearch.org or follow BRI’s Autoimmune Life Blog, Facebook, Instagram,  LinkedIn or Twitter to learn more.     The Clinical Research Project Coordinator coordinates projects and processes and provides administrative support within the Clinical Research Program (CRP) at the Benaroya Research Institute. Working with clinicians at the Virginia Mason Seattle Medical Center, the Clinical Research Program differentiates itself by focusing on patient-centered research. The Benaroya Research Institute is an independent, non-profit organization with a culture based on the values of collaboration, respect, innovation and inquiry. Team members work together to support patients and clinicians with the goal of better outcomes for all.

The Research Assistant will work to support the aims of the Type 1 Diabetes TrialNet Clinical Hub, a NIDDK-funded grant in the Diabetes Clinical Research Program. This position will serve on the Hub team working to further the primary goals of the TrialNet Hub:   - Assuring that neither recruitment nor operations are limiting factors in TrialNet meeting its’ clinical objectives. - Advancing systems and a culture that are sustainable and scalable, adaptable, and forward thinking. This position will be responsible for supporting the Type 1 Diabetes TrialNet Hub Project Manager (Operations and Recruitment) and Hub Program Manager, as well as assisting in a variety of duties related to TrialNet operations and recruitment activities. The Hub Research Assistant will largely focus on a variety of administrative details, systems management, and project support.

The Outreach Research Assistant is an essential member of the small team that promotes Benaroya Research Institute’s type 1 diabetes (T1D) research among patients, healthcare providers, and T1D groups throughout the Pacific Northwest; and that recruit’s participants for studies and clinical trials. The person in this role has daily interaction with individuals and healthcare providers via phone calls, emails, virtual meetings, and in-person; and has strong writing and in-person communication skills. A background or interest in medical science is helpful because you must be able to understand and describe studies in lay language to patients and their family members.    Duties include: - Daily administrative tasks such as answering emails and phone calls, data entry and making copies - Tracking outreach activities and recruitment numbers - Maintaining inventory of recruitment materials and blood draw supplies - Planning and supporting events and outreach programs   Along with having excellent communication and interpersonal skills, the ideal person for this role is a self-starter who is good at organizing and can prioritize tasks while working under deadlines. You must be able to work some evenings and weekends and travel occasionally. Finally, the Outreach Research Assistant is passionate about research that aims to improve the lives of people living with type 1 diabetes and other autoimmune diseases.

The Outreach Coordinator works with the Outreach Supervisor to promote Benaroya Research Institute’s type 1 diabetes (T1D) research to patients, healthcare providers, and T1D groups throughout the Pacific Northwest; and to recruit participants for studies and clinical trials. The role requires strong interpersonal and communication skills (both speaking and writing). An interest in medical science or research is helpful as you must describe research studies and clinical trials in language targeted to either healthcare professionals or a lay audience.   This role may involve recruitment for studies of other diseases of the immune system and therefore you’ll need the ability to quickly comprehend basic scientific concepts of autoimmune diseases and treatments in general. You’ll also write content for emails, letters, newsletters, and flyers that will both inform individuals and providers about study opportunities and engage their interest in study participation.   This role requires strong organizational skills, including making the best use of spreadsheets and online tools to manage contacts with clinics, healthcare providers, type 1 diabetes groups, and patients. Relationships with these groups are critical to our success and this role involves developing new partnerships while maintaining existing relationships using targeted outreach strategies. You must be able to juggle multiple priorities under deadline, work well independently and on a team, and remain calm and adaptable when traveling and during large in-person events. Administrative work is also a big part of this role, including tasks such as inventory management; making copies of study forms and recruitment materials; and daily fielding of phone calls, emails and online inquiries about research or troubleshooting requests. For all aspects of this role, the Outreach Coordinator must have a passion to support research that aims to improve the lives of people living with type 1 diabetes and other autoimmune diseases.   Must be available for overnight travel to research events and conferences in the Pacific Northwest, approximately three to four times per year. Must also be available an additional six to ten evenings and weekends per year, promoting studies and screening research participants locally.

Benaroya Research Institute at Virginia Mason (BRI) has a bold mission: Predict, prevent, reverse and cure immune system diseases, from autoimmune disease to cancer to COVID-19. We examine the immune system in both health and disease to understand how disorders start and how to rebalance the immune system back to health. Equipped with innovative tools and robust biorepositories, our team chips away at the biggest mysteries behind these conditions to work toward our vision of a healthy immune system for all. As an independent non-profit organization within Virginia Mason Franciscan Health, we collaborate with clinicians to accelerate the path from innovative lab discoveries to life-changing patient care.   At BRI, each role is valued and an important contributor to the vision and mission. BRI is committed to a safe, caring and diverse workplace; as well as to taking action to further our commitments to foster inclusion, equity and belonging so employees feel comfortable bringing their full selves to work. Consider making a difference, join our team. Because together, we are Powering Possibility.   Visit BenaroyaResearch.org or follow BRI’s Autoimmune Life Blog, Facebook, Instagram,  LinkedIn or Twitter to learn more.     The Clinical Research Coordinator I will have oversight of multiple studies and work closely with the Center for Interventional Immunology study team to recruit and enroll participants, with and without autoimmune disease, conduct study visits and maintain study records in accordance with specified protocol and procedures for the Translational Research Program Immune Mediated Disease Registry and Repository.    This is not a lab-based position.

Benaroya Research Institute at Virginia Mason (BRI) has a bold mission: Predict, prevent, reverse and cure immune system diseases, from autoimmune disease to cancer to COVID-19. We examine the immune system in both health and disease to understand how disorders start and how to rebalance the immune system back to health. Equipped with innovative tools and robust biorepositories, our team chips away at the biggest mysteries behind these conditions to work toward our vision of a healthy immune system for all. As an independent non-profit organization within Virginia Mason Franciscan Health, we collaborate with clinicians to accelerate the path from innovative lab discoveries to life-changing patient care.   At BRI, each role is valued and an important contributor to the vision and mission. BRI is committed to a safe, caring and diverse workplace; as well as to taking action to further our commitments to foster inclusion, equity and belonging so employees feel comfortable bringing their full selves to work. Consider making a difference, join our team. Because together, we are Powering Possibility.   Visit BenaroyaResearch.org or follow BRI’s Autoimmune Life Blog, Facebook, Instagram,  LinkedIn or Twitter to learn more.   The Research Assistant will work closely with the Translational Research Program study team to recruit and enroll participants, with and without autoimmune disease, conduct study visits and maintain study records in accordance with specified protocol and procedures for the Translational Research Program Immune Mediated Disease Registry and Repository.   This is not a lab-based position.

The Clinical Research Program at the Benaroya Research Institute at Virginia Mason (BRI) is committed to giving patients access to clinical trials.  Working with clinicians at Virginia Mason Franciscan Health (VMFH), the Clinical Research Program at BRI differentiates itself by focusing on patient-centered research.  BRI is an independent, non-profit organization with a culture based on the values of collaboration, respect, innovation and inquiry.  Team members work together to support patients and clinicians with the goal of better outcomes for all.   Visit BenaroyaResearch.org or follow BRI’s Autoimmune Life Blog, Facebook, Instagram,  LinkedIn or Twitter to learn more.     The Research Assistant (RA) would offer support in a variety of studies that we conduct as well as the various phases of study development. Benaroya Research Institute and the Cancer Clinical Research Unit encourage teamwork and collaboration. We have unparalleled support from our physicians, clinic staff and study staff. The RA will support the Clinical Research Coordinators and assist with a variety of duties related to the conduct of clinical research protocols. This is not a lab-based position.   This RA position will work within the Cancer Clinical Research Unit on a variety of oncology trials. At least 50% of this role will assist with the conduct of investigator-initiated non-interventional and biorepository trails, with remaining time spent on various interventional oncology trials.

The Data Collaboration Team (DCT) is charged with ensuring the accessibility and validity of research and operational data collected by the ITN’s clinical trials. We are a small and dynamic team that enjoys a great deal of flexibility in how we approach developing solutions, and we thrive when applying our skills and creativity to improving people’s lives.   In this role, you will be building and customizing on the applications and sites that allow our colleagues and collaborators to conduct clinical trials, explore the resulting data, and make our findings available to the public. Together, we support the ITN’s mission through meaningful and necessary work.

The Diabetes Clinical Research Program (DCRP) currently includes clinical trials of type 1 diabetes prevention and intervention as well clinical investigations involving basic physiology studies, analysis of immunologic markers, and epidemiological studies. The program conducts both grant funded and industry studies in type 1 diabetes and beyond.   Benaroya Research Institute’s research focus is immune mediated disease which ranges from basic discovery science to translational medicine, systems biology, genetics, and clinical trials.  We are in a superb research environment with established local collaborations in teaching and/or research with the University of Washington, Fred Hutch, Seattle Children’s Hospital, and other research centers throughout the Pacific Northwest.   A Clinical Research Coordinator I (CRC) performs a more complex set of tasks to facilitate clinical research which may include working with affiliate or collaborating research sites, as well as conducting BRI-based research studies. For investigator initiated studies, the coordinator may assist with protocol development, creation of operating manuals, drafting provider orders and source documents. The coordinator plays an integral role in process, study improvement, and efficiency, which is unique to this type of clinical research.