The Harrison Lab at the Benaroya Research Institute (BRI) in Seattle, WA is seeking highly-motivated postdoctoral candidates in the areas of mucosal immunology, specifically T and B cell responses to commensal microbes. Benaroya Research Institute is an internationally recognized medical research institute focused on finding cures for autoimmune and immune-mediated diseases. We stress excellence in advanced laboratory experimentation and carefully designed translational research programs. This offers our scientists the opportunity to directly impact the lives of people suffering from diseases including type 1 diabetes, rheumatoid arthritis, multiple sclerosis, allergies and asthma. The Harrison Lab (www.harrison-lab.org) works to understand the mechanisms controlling host-microbe interactions at barrier sites such as the skin and gastrointestinal tract. We study how our resident commensal microbes influence the development, education and function of our immune system. To do so, we utilize a multi-disciplinary approach combining development and implementation of tools to track commensal-specific T and B cells in healthy and inflamed tissues, with single-cell and population level transcriptomics and epigenetic analyses of T and B cell differentiation to investigate how the host mounts and regulates immunity to the microbiome.

The Kwok Lab uses class II MHC multimer reagents and other state of art technologies, including single cell RNAseq experiments in examining antigen specific CD4+ T Cells in infectious diseases, peanut allergy, type 1 diabetes and rheumatoid arthritis.

The Long Lab is a translational immunology lab focused on better understanding underlying mechanisms of the autoimmune disease, type 1 diabetes. This is done by performing mechanistic studies associated with clinical trials and in-depth studies using clinical samples.  In fact, we have been involved in the majority of studies cited in a recent Science T1D special section review (Science 373, 510-516, 2021).  This position provides the unique opportunity to focus on mechanistic studies associated with additional clinical trials in T1D targeting T cells or cytokine pathways.

This highly collaborative 2+ year position provides a unique opportunity for multi-disciplinary research spanning Systems Immunologyand the Human Immunophenotyping (HIP) Core/Long Lab, under the guidance of Dr. Hamid Bolouri and Dr. Alice Long. The HIP Coreand Long Labare translational immunology labs that study autoimmunity by using cytometry-based assays on samples from clinical trials paired with selected samples to better understand mechanisms of disease.  The Bolouri Lab is focused on developing and applying computational systems immunology methods to better understand immune dysregulation in autoimmunity, cancer, and infection. We are seeking a bioinformatics scholar with strong interests in high-dimensional flow and mass cytometry, omics technologies, and systems immunology, as well as deep expertise in the development and application of bioinformatics methods and tools to emerging challenges in immunology research. Together, we hope to foster creative thinking that will move the field closer to treatments of immune mediated diseases.

This highly collaborative postdoc position provides a unique opportunity for multi-disciplinary research  spanning Systems Immunologyand the Human Immunophenotyping (HIP) Core/Long Lab, under the guidance of Dr. Hamid Bolouri and Dr. Alice Long. The HIP Coreand Long Labare translational immunology labs that study autoimmunity by using cytometry-based assays on samples from clinical trials paired with selected samples to better understand mechanisms of disease.  The Bolouri Lab is focused on developing and applying computational systems immunology methods to better understand immune dysregulation in autoimmunity, cancer, and infection. We are seeking a bioinformatics scholar with strong interests in high-dimensional flow and mass cytometry, omics technologies, and systems immunology, as well as deep expertise in the development and application of bioinformatics methods and tools to emerging challenges in immunology research. Together, we hope to foster creative thinking that will move the field closer to treatments of immune mediated diseases.

Combatting Immune Disease Through Genomics Analysis   Come join our team  and help fight immune diseases   We need individuals to apply cutting edge big data approaches to study the human immune system. We believe that understanding how the immune system is broken in diseases like cancer and autoimmunity will lead to better patient care. We are looking for highly motivated and creative individuals who enjoy working in a multidisciplinary team-oriented environment to use Systems Biology approaches to discover new mechanisms, biomarkers and therapies for immune diseases.    Benaroya Research Institute at Virginia Mason (BRI) is an internationally recognized medical research institute committed to finding a cure for autoimmune and immune-mediated diseases, through a combination of basic and translational research programs. This means you can contribute to scientific advances that have a direct impact on people afflicted with these diseases, including type 1 diabetes, rheumatoid arthritis, multiple sclerosis, allergies, and asthma. BRI research leadership has identified Bioinformatics as a key enabling technology, so there is broad and strong support for the analysis, and visualization of research data.  

Combatting Immune Disease Through Systems Analysis    Come join our team and help fight immune diseases   We need individuals to apply cutting edge big data approaches to study of the human immune system. We believe that understanding how the immune system is broken in diseases like cancer and autoimmunity will lead to better patient care. We are looking for highly motivated and creative individuals who enjoy working in a multidisciplinary team-oriented environment to use Systems Biology approaches to help discover new mechanisms, biomarkers, and therapies for immune diseases. Successful candidates will receive a unique system of co-mentoring. They will reside in the Center for Systems Immunology at BRI and receive primary mentorship and training there. They will also collaborate closely with and be co-mentored by world class investigators expert in varied immune diseases and disease models throughout the Institute and elsewhere.

The Clinical Research Program (CRP) Specialist provides administrative support and independently coordinates projects within the CRP at Benaroya Research Institute. The CRP supports the implementation of clinical research studies at Virginia Mason Medical Center and the Benaroya Research Institute.

Join an international network of leading academic institutions, endocrinologists, physicians, scientists, and healthcare teams at the forefront of type 1 diabetes (T1D) research. At TrialNet we bring screening to those at high risk of developing T1D and advance innovative clinical studies testing ways to slow down and prevent disease progression to achieve our goal: a future without T1D.   The TrialNet Hub located at the Benaroya Research Institute in Seattle, WA is seeking an energetic thought leader and team player for the role of Project Manager – Communication and Engagement. The Project Manager will serve on the Hub team, working in partnership with the Hub Director and the Hub Program Manager to further the primary goals of the TrialNet Hub:   - Assuring that neither recruitment nor operations are limiting factors in TrialNet meeting its’ clinical objectives - Advancing systems and a culture that is sustainable, scalable, adaptable, and forward thinking.   The Project Manager will be responsible for the overall communication and engagement efforts supporting the Type 1 Diabetes TrialNet research portfolio. This position is responsible for developing and executing internal and external engagement and communication strategies, including branding and messaging designed to increase participant engagement, resources to support outreach and recruitment efforts for TrialNet studies, as well as internal member communications. The Project Manager will work closely with TrialNet leadership, study chairs, coordinators, and the TrialNet Coordinating Center to collaboratively implement strategic communication and engagement initiatives.   At the TrialNet Hub you will have the unique opportunity to work in a collaborative environment that emphasizes innovation and creativity and offers the opportunity to steer the messaging around type 1 diabetes research.

Benaroya Research Institute at Virginia Mason has a bold mission: Predict, prevent, reverse and cure immune system diseases, from autoimmune disease to cancer to COVID-19. We examine the immune system in both health and disease to understand how disorders start and how to rebalance the immune system back to health. Equipped with innovative tools and robust biorepositories, our team chips away at the biggest mysteries behind these conditions to work toward our vision of a healthy immune system for all. As an independent non-profit organization within Virginia Mason Franciscan Health, we collaborate with clinicians to accelerate the path from innovative lab discoveries to life-changing patient care   This position is open to candidates located anywhere within the U.S.A. The candidate will have the option to work remotely from home.

This translational immunologist collaborative position provides a unique opportunity to explore the potentially protective role of exhausted CD8 T cells in type 1 diabetes (T1D) by integrating immunology and systems biology skill sets. The Long Lab is a translational immunology lab focused on better understanding underlying mechanisms of autoimmune disease, patient variability, and response to therapy. Currently, we are primarily focused on three, inter-related projects in the setting of T1D: 1) Causes and consequences of reduced response to IL-2, 2) Differentiation and stability of CD8 T cell exhaustion associated with better outcome, and 3) identification of biomarkers of T1D severity. Each of these projects use human samples, are collaborative in context working with the diabetes team and systems immunology, and use the resources of the BRI Human Immunophenotyping (HIP) Core, supervised by Dr. Alice Long.

This translational immunologist collaborative position provides a unique opportunity to explore the potentially protective role of exhausted CD8 T cells in type 1 diabetes (T1D) by integrating immunology and systems biology skill sets.   The Long Lab is a translational immunology lab focused on better understanding underlying mechanisms of autoimmune disease, patient variability, and response to therapy.  Currently, we are primarily focused on three, inter-related projects in the setting of T1D: 1) Causes and consequences of reduced response to IL-2, 2) Differentiation and stability of CD8 T cell exhaustion associated with better outcome, and 3) identification of biomarkers of T1D severity.    Each of these projects use human samples, are collaborative in context working with the diabetes team and systems immunology, and use the resources of the BRI Human Immunophenotyping (HIP) Core, supervised by Dr. Alice Long. 

The Kwok Labat the Benaroya Research Institute (BRI) in Seattle, WA.  Is seeking a Postdoctoral Research Associate to join a lab that uses class II tetramer reagents and other state of art technologies, including single cell RNAseq experiments in examining antigen specific CD4+ T cells infectious diseases, peanut allergy, type 1 diabetes and rheumatoid arthritis.

The Clinical Research Coordinator I-II (CRC) performs increasingly complex tasks to facilitate clinical research, while providing service to Virginia Mason Physicians on their clinical trials specializing in Cardiology, Asthma/Allergy, Rheumatology, and Neurology. This is not a lab-based position.

The Research Assistant will work closely with the Translational Research Program study team to recruit and enroll participants, with and without autoimmune disease, conduct study visits and maintain study records in accordance with specified protocol and procedures for the Translational Research Program Immune Mediated Disease Registry and Repository. This is not a lab-based position.

The Research Assistant (RA) would offer support in a variety of studies that we conduct as well as the various phases of study development. Benaroya Research Institute and the Clinical Trials Unit encourage teamwork and collaboration. We have unparalleled support from our physicians, clinic staff and study staff. The RA will support the Clinical Research Coordinators and assist with a variety of duties related to the conduct of clinical research protocols. This is not a lab-based position.   This RA position will work within the Cancer Clinical Research Unit on a variety of oncology trials. At least 50% of this role will assist with the conduct of investigator-initiated non-interventional and biorepository trials, with remaining time spent on various interventional oncology trials.

The Administrative Assistant II provides administrative support and independently coordinates projects within the CRP at Benaroya Research Institute. The CRP supports the implementation of clinical research studies at Virginia Mason Medical Center and the Benaroya Research Institute.

A Clinical Research Coordinator (CRC) I-II performs an increasing complexity of tasks to facilitate clinical research which may include working with affiliate or collaborating research sites as well as conducting BRI based research studies. This position is based in the Cancer Clinical Research Unit, with patient visits occurring in the downtown Seattle Virginia Mason outpatient oncology clinic. The CRC I-II will manage a variety of oncology trials in Phases I – III. This position functions as part of a highly dynamic team of Coordinators and Research Assistants (RA), and requires the candidate to be on-site a majority of the time.  

The Buckner Lab is renowned for expertise in translational immunology and human autoimmune disease. Research in the Buckner Lab focuses on identifying the underlying mechanisms by which the adaptive immune response to self-antigen becomes pathogenic in the setting of human autoimmune study. They use cutting edge techniques and primary human immune cells to study the following autoimmune diseases: type 1 diabetes (T1D), rheumatoid arthritis (RA), muliple sclerosis (MS), systemic lupus erythematosus and irAE in Cancer immunotherapy.  They have extensive experience in MHC class II tetramers, T cell cloning, T and B cell functional assays, gene editing and phenotyping of human lymphocytes.   Potential projects in the Buckner Lab include: - Development of regulatory T cell - based therapies - Identification and characterization of antigen-specific T cells in rheumatoid arthritis - Genotype-phenotype studies of genetic variants associated with autoimmune disease - T cell response to cytokines in autoimmune disease. - irAE in the setting of cancer immunotherapies

The James Lab at the Benaroya Research Institute (BRI) in Seattle, WA is seeking a motivated Postdoctoral Research Associate to join our highly collaborative team. Research in the James Lab focuses on the study of antigen specific T cells using flow cytometry and emerging cutting edge technologies. Utilizing these tools, we seek to understand key targets of autoimmune attack, to develop informative biomarkers, and to explore mechanisms of disease progression in autoimmune disease.

The Research Assistant (RA) would offer support in a variety of studies that we conduct as well as the various phases of study development. Benaroya Research Institute and the Clinical Trials Unit encourage teamwork and collaboration. We have unparalleled support from our physicians, clinic staff and study staff.  We are searching for an RA that would support the Clinical Research Coordinators and assists with a variety of duties related to the conduct of oncology clinical research protocols.   This is not a lab-based position.

Benaroya Research Institute at Virginia Mason has a bold mission: Predict, prevent, reverse and cure immune system diseases, from autoimmune disease to cancer to COVID-19. We examine the immune system in both health and disease to understand how disorders start and how to rebalance the immune system back to health. Equipped with innovative tools and robust biorepositories, our team chips away at the biggest mysteries behind these conditions to work toward our vision of a healthy immune system for all. As an independent non-profit organization within Virginia Mason Franciscan Health, we collaborate with clinicians to accelerate the path from innovative lab discoveries to life-changing patient care. This position is open to candidates located anywhere within the U.S.A. The candidate will have the option to work remotely from home. 

This position will work collaboratively with IT and the Data Collaboration Team to lead the effort to design, implement, and automate test procedures for various aspects of software programs, such as usability, database impact, and error and bug finding. In addition, the Software Test Engineer will identify, analyze and create detailed records of problems that appear during testing and work directly with software developers and IT to find solutions and develop retesting procedures.

Benaroya Research Institute at Virginia Mason (BRI) is an independent non-profit organization within Virginia Mason Franciscan Health.  We collaborate with clinicians to accelerate the path from innovative lab discoveries to life-changing patient care. This position is designed to provide monitoring services (approximately 65-75% of the time) for clinical research trials performed primarily at Virginia Mason Franciscan Health with a secondary responsibility to assist with staff training and education, document control, CAPA creation assistance and follow-up, and other study staff support as needed. Monitoring work typically focuses on moderate to high-risk studies, with special emphasis on Sponsor-Physician research and oncology studies. As an internal monitor, this position will work with the research staff to assure fundamental clinical research knowledge, mistake-proofing, and long-term success.

The Campbell Lab is examining how factors such as diet, prior infection history and microbiome shape the abundance and function of Treg cells in different tissue sites, and how this in turn impacts tolerance induction, development of autoimmune disease and responses to immune-modulating therapy.   Part time (12 – 19 hours per week), flexible hours between 8:00 AM to 5:00 PM, not weekends.