The Harrison Lab at the Benaroya Research Institute (BRI) in Seattle, WA is seeking highly-motivated postdoctoral candidates in the areas of mucosal immunology, specifically T and B cell responses to commensal microbes. Benaroya Research Institute is an internationally recognized medical research institute focused on finding cures for autoimmune and immune-mediated diseases. We stress excellence in advanced laboratory experimentation and carefully designed translational research programs. This offers our scientists the opportunity to directly impact the lives of people suffering from diseases including type 1 diabetes, rheumatoid arthritis, multiple sclerosis, allergies and asthma. The Harrison Lab (www.harrison-lab.org) works to understand the mechanisms controlling host-microbe interactions at barrier sites such as the skin and gastrointestinal tract. We study how our resident commensal microbes influence the development, education and function of our immune system. To do so, we utilize a multi-disciplinary approach combining development and implementation of tools to track commensal-specific T and B cells in healthy and inflamed tissues, with single-cell and population level transcriptomics and epigenetic analyses of T and B cell differentiation to investigate how the host mounts and regulates immunity to the microbiome.

This highly collaborative 2+ year position, at the Benaroya Research Institute, provides a unique opportunity for multi-disciplinary research spanning Systems Immunologyand the Human Immunophenotyping (HIP) Core/Long Lab, under the guidance of Dr. Hamid Bolouri and Dr. Alice Long. The HIP Coreand Long Labare translational immunology labs that study autoimmunity by using cytometry-based assays on samples from clinical trials paired with selected samples to better understand mechanisms of disease.  The Bolouri Lab is focused on developing and applying computational systems immunology methods to better understand immune dysregulation in autoimmunity, cancer, and infection. We are seeking a bioinformatics scholar with strong interests in high-dimensional flow and mass cytometry, omics technologies, and systems immunology, as well as deep expertise in the development and application of bioinformatics methods and tools to emerging challenges in immunology research. Together, we hope to foster creative thinking that will move the field closer to treatments of immune mediated diseases.

This highly collaborative postdoc position, at the Benaroya Research Institute, provides a unique opportunity for multi-disciplinary research spanning Systems Immunologyand the Human Immunophenotyping (HIP) Core/Long Lab, under the guidance of Dr. Hamid Bolouri and Dr. Alice Long at the Benaroya Research Institute.  The HIP Coreand Long Labare translational immunology labs that study autoimmunity by using cytometry-based assays on samples from clinical trials paired with selected samples to better understand mechanisms of disease.  The Bolouri Lab is focused on developing and applying computational systems immunology methods to better understand immune dysregulation in autoimmunity, cancer, and infection. We are seeking a bioinformatics scholar with strong interests in high-dimensional flow and mass cytometry, omics technologies, and systems immunology, as well as deep expertise in the development and application of bioinformatics methods and tools to emerging challenges in immunology research. Together, we hope to foster creative thinking that will move the field closer to treatments of immune mediated diseases.

This translational immunologist collaborative position, at the Benaroya Research Institute, provides a unique opportunity to explore the potentially protective role of exhausted CD8 T cells in type 1 diabetes (T1D) by integrating immunology and systems biology skill sets. The Long Lab is a translational immunology lab focused on better understanding underlying mechanisms of autoimmune disease, patient variability, and response to therapy. Currently, we are primarily focused on three, inter-related projects in the setting of T1D: 1) Causes and consequences of reduced response to IL-2, 2) Differentiation and stability of CD8 T cell exhaustion associated with better outcome, and 3) identification of biomarkers of T1D severity. Each of these projects use human samples, are collaborative in context working with the diabetes team and systems immunology, and use the resources of the BRI Human Immunophenotyping (HIP) Core, supervised by Dr. Alice Long.

This translational immunologist collaborative position provides a unique opportunity to explore the potentially protective role of exhausted CD8 T cells in type 1 diabetes (T1D) by integrating immunology and systems biology skill sets.   The Long Lab, at the Benaroya Research Institute, is a translational immunology lab focused on better understanding underlying mechanisms of autoimmune disease, patient variability, and response to therapy.  Currently, we are primarily focused on three, inter-related projects in the setting of T1D: 1) Causes and consequences of reduced response to IL-2, 2) Differentiation and stability of CD8 T cell exhaustion associated with better outcome, and 3) identification of biomarkers of T1D severity.    Each of these projects use human samples, are collaborative in context working with the diabetes team and systems immunology, and use the resources of the BRI Human Immunophenotyping (HIP) Core, supervised by Dr. Alice Long. 

The Buckner Lab at the Benaroya Research Institute in Seattle, Washington is renowned for expertise in translational immunology and human autoimmune disease. Research in the Buckner Lab focuses on identifying the underlying mechanisms by which the adaptive immune response to self-antigen becomes pathogenic in the setting of human autoimmune study. They use cutting edge techniques and primary human immune cells to study the following autoimmune diseases: type 1 diabetes (T1D), rheumatoid arthritis (RA), muliple sclerosis (MS), systemic lupus erythematosus and irAE in Cancer immunotherapy.  They have extensive experience in MHC class II tetramers, T cell cloning, T and B cell functional assays, gene editing and phenotyping of human lymphocytes.   Potential projects in the Buckner Lab include: - Development of regulatory T cell - based therapies - Identification and characterization of antigen-specific T cells in rheumatoid arthritis - Genotype-phenotype studies of genetic variants associated with autoimmune disease - T cell response to cytokines in autoimmune disease. - irAE in the setting of cancer immunotherapies

This entry level research technician position provides a unique opportunity to learn new concepts and techniques while working with PhD level scientists to determine the potentially protective role of exhausted CD8 T cells in type 1 diabetes (T1D), building from past publications (Long, et.al., Sci Imm, Wiedeman, et.al., JCI). The Long Lab is a translational immunology lab focused on better understanding underlying mechanisms of autoimmune disease, patient variability, and response to therapy. Currently, we are primarily focused on three, inter-related projects in the setting of T1D: 1) Causes and consequences of reduced response to IL-2, 2) Differentiation and stability of CD8 T cell exhaustion associated with better outcome, and 3) identification of biomarkers of T1D severity. Each of these projects use human samples, are collaborative in context working with the diabetes team and systems immunology, and use the resources of the BRI Human Immunophenotyping (HIP) Core. By providing these opportunities, I hope to foster creative thinking and collaboration in my lab that will move the field closer to treatments of autoimmunity. This learning environment has enabled multiple technicians from my lab to successfully move to higher education (graduate school, medical school) and more advanced positions in industry. 

The Clinical Research Coordinator II (CRC) performs increasingly complex tasks to facilitate clinical research, while providing service to Virginia Mason Physicians on their clinical trials specializing in Cardiology, Asthma/Allergy, Rheumatology, and Neurology. Strong communication and organization skills are required.   This position would offer a variety in studies that we conduct as well as the various phases of study development. Benaroya Research Institute and the Clinical Trials Unit encourage teamwork and collaboration. We have unparalleled support from our physicians, clinic staff and study staff.

The Clinical Research Project Coordinator coordinates projects and processes and provides administrative support within the Clinical Research Program (CRP) at the Benaroya Research Institute. Working with clinicians at the Virginia Mason Seattle Medical Center, the Clinical Research Program differentiates itself by focusing on patient-centered research. The Benaroya Research Institute is an independent, non-profit organization with a culture based on the values of collaboration, respect, innovation and inquiry. Team members work together to support patients and clinicians with the goal of better outcomes for all.

The Clinical Research Coordinator I will have oversight of multiple studies and work closely with the Center for Interventional Immunology study team to recruit and enroll participants, with and without autoimmune disease, conduct study visits and maintain study records in accordance with specified protocol and procedures for the Translational Research Program Immune Mediated Disease Registry and Repository.    This is not a lab-based position.

Combatting Immune Disease Through Genomics Analysis! Come join our team and help fight immune diseases.    We need individuals to apply cutting edge big data approaches to study the human immune system. We believe that understanding how the immune system is broken in diseases like cancer and autoimmunity will lead to better patient care. We are looking for highly motivated and creative individuals who enjoy working in a multidisciplinary team-oriented environment to use Systems Biology approaches to discover new mechanisms, biomarkers and therapies for immune diseases.    Benaroya Research Institute at Virginia Mason (BRI) is an internationally recognized medical research institute committed to finding a cure for autoimmune and immune-mediated diseases, through a combination of basic and translational research programs. This means you can contribute to scientific advances that have a direct impact on people afflicted with these diseases, including type 1 diabetes, rheumatoid arthritis, multiple sclerosis, allergies, and asthma. BRI research leadership has identified Bioinformatics as a key enabling technology, so there is broad and strong support for the analysis, and visualization of research data.  

The Benaroya Research Institute is offering an opportunity for an early career clinical scientist to join our Diabetes Program.  As a leader in immunology discovery and clinical research, the Benaroya Research Institute in Seattle, WA provides a unique environment for a physician investigator to focus on understanding the immune and metabolic causes and consequences of human autoimmunity and Type 1 diabetes.  We offer a superb training environment for early investigators. The BRI faculty include outstanding NIH funded laboratory and clinically based investigators providing a robust scientific milieu and focused mentorship to facilitate the development of clinician scientists.  Our group has leadership roles in NIH sponsored programs such as Diabetes TrialNet and the Immune Tolerance Network providing networking opportunities for early career investigators.  Based in Seattle, we are in a robust research environment with established collaborations in teaching and/or research with the University of Washington, Fred Hutch Cancer Center, Seattle Children’s Hospital and Research Institute, and industry partners. For pediatricians, the position may include joint clinical appointments with Seattle Children’s Hospital.

The Clinical Research Center (CRC) is an outpatient, hospital-based clinic which provides nursing services for pediatric and adult participants enrolled in research studies, with an emphasis on autoimmune diseases (particularly Type 1 Diabetes), and immune therapies. The Registered Nurse supports and supplements regular staff during high census days and in other special circumstances, by providing various nursing services including:  - Starting IVs - Infusing investigational agents - Performing blood draws - Checking vital signs - Monitoring for adverse events - Other required nursing support to the research staff The Per Diem Registered Nurse will cover primarily day shift hours, though evening and night shifts may periodically be offered.  Due to the nature of scheduling on the CRC, the available shifts offered to the Per Diem pool often vary substantially from one month to the next. Flexibility and availability are key qualities in the Per Diem RN team. The usual operating times of the CRC are 7:30 am to 4:00 pm, Monday through Friday. 

The Research Assistant will work closely with the Translational Research Program study team to recruit and enroll participants, with and without autoimmune disease, conduct study visits and maintain study records in accordance with specified protocol and procedures for the Translational Research Program Immune Mediated Disease Registry and Repository.   This is not a lab-based position.

BRI offers college undergraduates the chance to expand their learning experiences beyond the traditional classroom through its in-person Summer Internship Program. The 8-week internship offers top-achieving and highly motivated science students the opportunity to work and learn under the mentorship of BRI's renowned researchers. The 2023 summer internship will run from June 20th-August 11th, 2023.    This position is for 20 hours per week and will be paid $18.69 per hour.

Postbaccalaureate Research Associate (Postbaccs) at Benaroya Research Institute (BRI) will engage in research at the forefront of immunologic, allergic, and infectious diseases, to prepare them for future careers in biomedical research. Postbaccs spend two years performing full-time research under the guidance and direction of a BRI Principal Investigator. Postbaccs have the opportunity to engage and network with experts in diverse scientific research fields while taking advantage of the extensive resources of BRI. Postbaccs will participate in a structured educational program in preparation for graduate or medical school including training in laboratory and/or computational skills, critical thinking, and scientific communication skills. Postbaccs will conduct research in BRI laboratories located in Seattle, WA, which provides a unique scientific research training environment in basic, translational, and clinical research for recent college graduates who plan to apply to graduate or professional school (Ph.D., M.D., or equivalent graduate degree).   Application deadline: March 1st 2023 Program start: July 5th 2023.   Application requirements: Apply online and include the items listed below: - Curriculum Vitae, including Education, Research Experience, Employment History, Awards and Honors - Transcript (unofficial) - Personal statement (1500 word limit). This statement should include the following: (a)  Educational background (b)  Description of previous research experience (c)  Research interests (d)  Career goals (e)  How the BRI Postbacc program will help you to reach your career goals - Additional statement (500 word limit): Describe an obstacle or challenge you have faced, and how you have overcome it. - Letters of Reference: 3 letters of reference. At least two must be from academic faculty familiar with applicant’s coursework or research experience. Your references must be confidential and emailed directly to postbacc@benaroyaresearch.org by the application deadline. Please email postbacc@benaroyaresearch.org with any questions about the program or application process.

The Animal Cage Washer is needed to provide the basic husbandry needs of the rodents housed in the vivarium by cleaning and sterilizing caging and other equipment while maintaining supplies and the general appearance and cleanliness of the facility. 

GENOMIC ANALYSIS OF IMMUNE CELLS IN RESPONSE TO THERAPY IN CANCER AND AUTOIMMUNE DISEASE.  Come join our team and help fight immune diseases!    The Linsley Lab is broadly engaged in basic and applied studies using complex systems theory, high throughput techniques as well as mathematical and computational tools to understand the functioning of the immune system in health and disease. The group works closely with informaticians and immunologists in many groups at BRI, resulting in a rich environment for quantitative, computational, and laboratory collaborations in immune disease research. Funding is available for two years, contingent upon periodic reviews, with an expectation of extension and expansion. Opportunities for training, conference attendance and publication are available.